Dynamics of circulating calprotectin accurately predict the outcome of moderate COVID-19 patients순환하는 칼프로텍틴의 역학은 중등도의 COVID-19 환자의 결과를 정확하게 예측합니다Article Published on 2022-06-012022-09-11 Journal: EBioMedicine [Category] MERS, 바이오마커, 진단, [키워드] Admission age alarmin Algorithm baseline Biomarker body mass body mass index calprotectin circulating Cohort collected Comorbidities Comorbidity Course COVID-19 COVID19 death defined Diagnosis disease severity Dynamics foundation France Gustave Roussy high risk Hospitalization Hospitalized identify independent intensive care intensive care unit joint latent class measure mixture model moderate Moderate COVID-19 MONITOR outcome Patient patients patients with moderate performed Peripheral blood plasma predict Predictive Predictive value Probability Research risk S100A8 S100A8/A9 S100A9 Serial measurement. serum severe COVID-19 Sex standard care Support Thermofisher trajectory transfer [DOI] 10.1016/j.ebiom.2022.104077 PMC 바로가기 [Article Type] Article
Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity유전자 연관성 데이터의 소음-증류 방향성 클러스터링Research Article Published on 2022-01-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting applied approach approach association biological pathway biological pathways BMI body mass body mass index can not Cluster Clustering complex Coronary heart disease correlated directional disease Effect elevated estimate generate Genetic genetic association Genetic variant genetic variants Genome-wide association studies group heart disease identify include Inflammation insight mechanism mechanisms Mendelian randomization analyses Mendelian randomization analysis mixture model obesity outliers provide question reduced risk robustness similarity statistical Support thought traits variant variants [DOI] 10.1371/journal.pgen.1009975 PMC 바로가기 [Article Type] Research Article
Quantifying previous SARS-CoV-2 infection through mixture modelling of antibody levels항체 수준의 혼합물 모델링을 통한 이전 SARS-CoV-2 감염 정량화Article Published on 2021-10-262022-09-12 Journal: Nature Communications [Category] MERS, SARS, 진단, [키워드] adjusted Analysis antibody antibody waning approach approach calculated country COVID-19 Epidemiology estimate infected with SARS-CoV-2 Infection Infectious-disease diagnostics mixture mixture model offer pathogen PCR-confirmed proportion SARS-CoV-2 SARS-COV-2 infection sensitivity Sensitivity and specificity Serosurvey Serosurveys Statistical methods symptomatic threshold Vaccination strategies Vaccination strategy [DOI] 10.1038/s41467-021-26452-z PMC 바로가기 [Article Type] Article
Risk factors associated with severe hospital burden of COVID-19 disease in Regione Lombardia: a cohort studyObservational Study Published on 2021-10-072022-10-04 Journal: BMC Infectious Diseases [Category] MERS, SARS, 임상, [키워드] Admission age appear approach association being Characteristics cohort study contributed COVID-19 COVID-19 disease Critical care death decrease discharge event example Factor Final First wave healthcare healthcare worker hospital hospital management Hospital-fatality risk hypothesised ICU ICU admission improvement increased risk Infection Italy knowledge Length lockdown Lombardia mixture model Mortality mortality risk Multi-state model Non-survivors Observational cohort study Odds ratio outcome pathway Patient PCR-confirmed performed progression Protective public health reduced risk Regression Result risk risk factor supplementary material Surveillance Survivors Treatment understanding [DOI] 10.1186/s12879-021-06750-z PMC 바로가기 [Article Type] Observational Study
Role of ATP in the RNA Translocation Mechanism of SARS-CoV-2 NSP13 HelicaseSARS-CoV-2 NSP13 헬리카제의 RNA 전위 메커니즘에서 ATP의 역할Article Published on 2021-08-122022-09-11 Journal: The journal of physical chemistry. B [Category] SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] antiviral target antivirals ATP binding characterized Clustering conserved Coronavirus infections COVID-19 pandemic demonstrated develop discriminant analysis domain Helicase identify investigated knowledge Linear Discriminant Analysis maintain mechanism mixture model molecular dynamics Molecular dynamics simulation motif nsp13 Numerous Population Protein protocol RNA role SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 nsp13 SF1 ssRNA Structure Support target Therapeutics translocate translocation treat Viral RNA was used [DOI] 10.1021/acs.jpcb.1c04528 PMC 바로가기 [Article Type] Article
The role of C-reactive protein as a prognostic marker in COVID-19COVID-19에서 예후 마커로서의 C 반응성 단백질의 역할Covid-19 Published on 2021-04-032022-09-10 Journal: International Journal of Epidemiology [Category] SARS, 바이오마커, [키워드] acute phase acute phase reactant Admission age analysed assist bimodal bimodal distribution Bootstrapping C-reactive protein C-reactive protein (CRP Care care planning Characteristics clinician Cohort collected COPE COVID-19 COVID-19 disease COVID-19 disease severity Cox regression criterion CRP cut-off determine diagnosis of COVID-19 distribution elevated Evidence hospital indicated Indicator Infection Inflammation information investigated linear mixture model mixture models Mortality non-specific not affected observation on admission Patient patients patients hospitalized performed predict prognostic Prognostic marker Result Severe infection threshold Treatment Trigger trimodal utility validation cohort was used with COVID-19 [DOI] 10.1093/ije/dyab012 PMC 바로가기 [Article Type] Covid-19
Economic Stressors, COVID-19 Attitudes, Worry, and Behaviors among U.S. Working Adults: A Mixture AnalysisArticle Published on 2021-02-272022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] affective Behavior CDC center cognitive Compliance conservation Control COVID-19 dataset economic stressors financial inadequacy global pandemic group Health increasingly individual Job insecurity mixture mixture model Novel coronavirus predictor predictors Prevent public health representing Research secure significant difference significantly Spread stressors suggested tested virus working Worry [DOI] 10.3390/ijerph18052338 PMC 바로가기 [Article Type] Article
Estimating the cumulative incidence of SARS-CoV-2 with imperfect serological tests: Exploiting cutoff-free approaches불완전한 혈청 검사로 SARS-CoV-2의 누적 발생률 추정: 차단 없는 접근 방식 활용Research Article Published on 2021-02-262022-09-12 Journal: PLoS Computational Biology [Category] MERS, 진단, [키워드] Accuracy antibody Antibody Response Antibody responses approach approach Asymptomatic asymptomatic infection Blood can be used circumvent confirmed case confirmed cases controls cumulative cumulative incidence Cutoff determine distribution elicit error estimate estimation False negative false negative results False positive fraction Guidance identify incidence individual individuals Infection leads less marker measure Measures Mild mixture model outperform pandemic parameter pathogen Pathogens Population Prevalence provided quantitative test required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody Sensitivity and specificity sera serological serological test Serological testing Serological tests seropositive seropositive individual seropositive individuals Serosurvey Serosurveys serum specific antibodies specific type specific types statistical statistical inference the SARS-CoV-2 to define yielding [DOI] 10.1371/journal.pcbi.1008728 PMC 바로가기 [Article Type] Research Article